EMERGING STRATEGIES IN BUCCAL DRUG DELIVERY: FROM CONCEPT TO CLINICAL APPLICATIONS

Abbas S

S. Abbas Priyadarshini Institute of Pharmaceutical Education and Research, 5th Mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India.
s.abbasaliabbasali@gmail.com

Abstract

When a medication is administered through the buccal mucosa, it dissolves and is absorbed into your bloodstream through a systematic circulation. This is known as the buccal drug delivery system. There are medications, films, and sprays available for both buccal and sublingual use. The review gives information on the anatomy and physiology of the oral cavity, the components and structure of the buccal mucosa, the benefits and drawbacks of the mucus layer, and the buccal delivery system. Information on barriers, mucus, and saliva; the various polymers used in mucoadhesive drug delivery systems; theories of buccal drug delivery; adhesion and evaluation that occur in these drug delivery methods; and the various commercially available dosage forms on the market. In recent years, the Buccal Drug Delivery System (BDDS) has attracted a lot of interest as a successful systemic drug delivery technique. Buccal patches in particular have many benefits, including avoiding hepatic first-pass metabolism, increasing bioavailability, guaranteeing user-friendliness, and boosting patient compliance. These systems provide quick medication absorption and action onset because of the buccal mucosa's rich vascularization. Novel mucoadhesive polymers, nanoparticulate systems, enzyme inhibitors, and cutting-edge drug delivery technologies including 3D printing and thermos-sensitive patches are examples of BDDS advancements. The overall goal of this analysis is to offer insightful information about the state of buccal drug delivery today, as well as any new advancements and prospects in the field. There by aiding in the design and development of more effective.

Keywords: Mucosal membrane, Mucoadhesive, Buccal absorption, Bio adhesive polymers, Buccal drug delivery system

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